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Physiologic and Social Stressors and Health during the Menopausal Transition

This project will be embedded in the longstanding cohort study, Project Viva, led by Harvard Pilgrim Health Care. Project Viva is a cohort of over 2,000 mother-child pairs who were enrolled when the mother was pregnant between 1999-2002 and who continue to be engaged in follow up data collection. Focusing on the moms, the investigators in this study will examine physiological and social stressors in early life and around the time of pregnancy as predictors of body composition, neuropsychiatric symptoms, and sleep duration and quality as these women now reach mid-life.

Project Publications

“Associations of hypertensive disorders of pregnancy and gestational diabetes mellitus with menopausal symptoms at midlife in Project Viva” Menopause. Soria-Contreras DC, Perng W, Rifas-Shiman SL, Mínguez-Alarcón L, Hivert MF, Shifren J, Oken E, Chavarro JE.

“Longitudinal associations of psychosocial stressors with menopausal symptoms and well-being among women in midlife” Menopause. Faleschini S, Tiemeier H, Rifas-Shiman SL, Rich-Edwards J, Joffe H, Perng W, Shifren J, Chavarro JE, Hivert MF, Oken E.

“Perceived stress and markers of ovarian reserve among subfertile women” Reproductive Biomedicine Online. Mínguez-Alarcón L, Williams PL, Souter I, Ford JB, Hauser R, Chavarro JE; Earth Study Team.

“Self-reported menstrual cycle length during reproductive years in relation to menopausal symptoms at midlife in Project Viva” Menopause. Mínguez-Alarcón L, Rifas-Shiman SL, Soria-Contreras DC, Hivert MF, Shifren J, Oken E, Chavarro JE.

“Associations of adverse childhood and lifetime experiences with sleep quality and duration among women in midlife” Sleep Health. Oken E, Rifas-Shiman SL, Joffe H, Manson JE, Spagnolo PA, Bertisch SM, Klerman EB, Chavarro JE.

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